摘要 :
pi-pi Interactions play an important role in the stability of protein structures. In the present study, we have analyzed the influence of n-n interactions in eNOS and nNOS proteins. The contribution of these pi-pi interacting resi...
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pi-pi Interactions play an important role in the stability of protein structures. In the present study, we have analyzed the influence of n-n interactions in eNOS and nNOS proteins. The contribution of these pi-pi interacting residues in sequential separation, secondary structure involvement, solvent accessibility and stabilization centers has been evaluated, pi-pi interactions stabilize the core regions within eNOS and nNOS proteins, pi-pi interacting residues are evolutionary conserved. There is a significant number of tc-tc interactions in spite of the lesser natural occurrences of pi-residues in eNOS and nNOS proteins. In addition to n-n interactions, n residues also formpi-pi networks in both eNOS and nNOS proteins which might play an important role in the structural stability of these protein structures.
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